CaMKII targets Bcl10 in T-cell receptor induced activation of NF-κB.

@article{Oruganti2011CaMKIITB,
  title={CaMKII targets Bcl10 in T-cell receptor induced activation of NF-κB.},
  author={Sreenivasa Rao Oruganti and Sofia Edin and Christine Grundstr{\"o}m and Thomas Grundstr{\"o}m},
  journal={Molecular immunology},
  year={2011},
  volume={48 12-13},
  pages={1448-60}
}
Recognition of antigen by T- or B-cell receptors leads to formation of an immunological synapse and initiation of signalling events that collaborate to determine the nature of the adaptive immune response. Activation of NF-κB transcription factors has a key role in regulation of numerous genes with important functions in immune responses and inflammation and is of great importance for lymphocyte activation and differentiation. The activation of NF-κB depends on changes in intracellular Ca(2… CONTINUE READING
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