CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP

@article{Mayford1995CaMKIIRT,
  title={CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP},
  author={Mark Mayford and Jian Wang and Eric R Kandel and Thomas J O'Dell},
  journal={Cell},
  year={1995},
  volume={81},
  pages={891-904}
}
To investigate the function of the autophosphorylated form of CaMKII in synaptic plasticity, we generated transgenic mice that express a kinase that is Ca2+ independent as a result of a point mutation of Thr-286 to aspartate, which mimics autophosphorylation. Mice expressing the mutant form of the kinase show an increased level of Ca(2+)-independent CaMKII activity similar to that seen following LTP. The mice nevertheless exhibit normal LTP in response to stimulation at 100 Hz. However, at… CONTINUE READING
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