CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages.

@article{Liu2008CaMKIIPT,
  title={CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages.},
  author={Xingguang Liu and M Yao and Nan Li and Chunmei Wang and Yuanyuan Zheng and Xuetao Cao},
  journal={Blood},
  year={2008},
  volume={112 13},
  pages={4961-70}
}
Calcium and its major downstream effector, calcium/calmodulin-dependent protein kinase II (CaMKII), are found to be important for the functions of immune cells. Lipopolysaccharide (LPS) has been shown to induce intracellular calcium release in macrophages; however, whether and how CaMKII is required for Toll-like receptor (TLR) signaling remain unknown. Here we demonstrate that TLR 4, 9, and 3 ligands markedly induce intracellular calcium fluxes and activate CaMKII-alpha in macrophages… CONTINUE READING
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