CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury.

@article{VilaPetroff2007CaMKIIIP,
  title={CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury.},
  author={Mart{\'i}n G Vila-Petroff and Margarita A Salas and M. Bakheit Said and Carlos A. Valverde and Luciana Sapia and Enrique L Portiansky and Roger J. Hajjar and Evangelia G Kranias and Cecilia Mundi{\~n}a-Weilenmann and Alicia R. Mattiazzi},
  journal={Cardiovascular research},
  year={2007},
  volume={73 4},
  pages={689-98}
}
OBJECTIVES Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) has been implicated in the regulation of cardiac excitation-contraction coupling (ECC) as well as in apoptotic signaling and adverse remodeling. The goal of the present study is to investigate the role of CaMKII in irreversible ischemia and reperfusion (I/R) injury. METHODS Isovolumic Langendorff perfused rat hearts were subjected to global no-flow I/R (45 min/120 min), and isolated myocytes were subjected to a protocol of… CONTINUE READING
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