CaMKIIβ regulates oligodendrocyte maturation and CNS myelination.

@article{Waggener2013CaMKIIRO,
  title={CaMKIIβ regulates oligodendrocyte maturation and CNS myelination.},
  author={Christopher T Waggener and Jeffrey L Dupree and Ype Elgersma and Babette Fuss},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 25},
  pages={
          10453-8
        }
}
CNS myelination and the maturation of the myelinating cells of the CNS, namely oligodendrocytes, are thought to be regulated by molecular mechanisms controlling the actin cytoskeleton. However, the exact nature of these mechanisms is currently only poorly understood. Here we assessed the role of calcium/calmodulin-dependent kinase type II (CaMKII), in particular CaMKIIβ, in oligodendrocyte maturation and CNS myelination. Using in vitro culture studies, our data demonstrate that CaMKIIβ is… CONTINUE READING

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