CaM-kinaseII-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation

@article{Krakstad2006CaMkinaseIIdependentCT,
  title={CaM-kinaseII-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation},
  author={Camilla Krakstad and Lars Herfindal and Bj\orn Tore Gjertsen and Reidulv B\oe and Olav Karsten Vintermyr and Kari Espolin Fladmark and Stein Ove D\oskeland},
  journal={Cell Death and Differentiation},
  year={2006},
  volume={13},
  pages={1191-1202}
}
The protein phosphatase inhibitor microcystin-LR (MC) induced hepatocyte apoptosis mediated by the calcium-calmodulin-dependent multifunctional protein kinase II (CaMKII). CaMKII antagonists were added at various times after MC to define for how long the cells depended on CaMKII activity to be committed to execute the various parameters of death. Shrinkage and nonpolarized budding were reversible and not coupled to commitment. A critical commitment step was observed 15–20 min after MC (0.5 μM… CONTINUE READING

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