CaM kinase II phosphorylation of slo Thr107 regulates activity and ethanol responses of BK channels

@article{Liu2006CaMKI,
  title={CaM kinase II phosphorylation of slo Thr107 regulates activity and ethanol responses of BK channels},
  author={Jianxi Liu and Maria T Asuncion-Chin and Pengchong Liu and Alex M Dopico},
  journal={Nature Neuroscience},
  year={2006},
  volume={9},
  pages={41-49}
}
High-conductance, Ca2+-activated and voltage-gated (BK) channels set neuronal firing. They are almost universally activated by alcohol, leading to reduced neuronal excitability and neuropeptide release and to motor intoxication. However, several BK channels are inhibited by alcohol, and most other voltage-gated K+ channels are refractory to drug action. BK channels are homotetramers (encoded by Slo1) that possess a unique transmembrane segment (S0), leading to a cytosolic S0–S1 loop. We… CONTINUE READING

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View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 55 references

a BK channel cocktail in C

Crowder, C. M. Ethanol targets
elegans. Trends Neurosci. 27, 579–582 • 2004

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