CaM-kinase II dephosphorylates Thr(286) by a reversal of the autophosphorylation reaction.

Abstract

Autophosphorylation of CaM-kinase II produces a form of the enzyme not requiring Ca(2+)/calmodulin for sustained activity. We report that autophosphorylated CaM-kinase II dephosphorylates itself in the presence of ADP (termed autodephosphorylation). The dephosphorylation was unaffected by phosphatase inhibitors and was nucleotide specific, occurring with… (More)

Topics

  • Presentations referencing similar topics