CaM kinase II as frequency decoder of Ca2+ oscillations.

  title={CaM kinase II as frequency decoder of Ca2+ oscillations.},
  author={Genevi{\`e}ve Dupont and Albert Goldbeter},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={20 8},
In many cell types, Ca2+ signals are organized in the form of repetitive spikes. The frequency of these intracellular Ca2+ oscillations increases with the level of stimulation, suggesting the existence of a frequency encoding phenomenon. The question arises as to how the frequency of Ca2+ oscillations can be decoded inside the cell. Ca2+/calmodulin kinase… CONTINUE READING