CaIPF7817 is involved in the regulation of redox homeostasis in Candida albicans.

Abstract

CaIPF7817, a functionally unknown gene in Candida albicans, was suggested to be involved in the redox system previously, but its exact role is unknown. In this study, ipf7817 null mutant was generated with the URA-blaster method. After the deletion of CaIPF7817, intracellular levels of reactive oxygen species were significantly increased; mitochondrial membrane potential, a direct indicator of mitochondrial function, was elevated; some important redox-related genes, including GLR1, SOD2, and TRR1, were up-regulated; and the GSH/GSSG ratio was raised. These changes indicated that CaIPF7817 played important roles in the regulation of redox homeostasis in C. albicans.

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Cite this paper

@article{Jia2007CaIPF7817II, title={CaIPF7817 is involved in the regulation of redox homeostasis in Candida albicans.}, author={Jian-Hui Jia and Yan Wang and Yong-bing Cao and Ping-hui Gao and Xin-ming Jia and Zhi-Ping Ma and YongGang Xu and Bao-di Dai and Yuanying Jiang}, journal={Biochemical and biophysical research communications}, year={2007}, volume={359 1}, pages={163-7} }