Ca2 +‐mobilizing hormones elicit phosphatidylethanol accumulation via phospholipase D activation

  title={Ca2 +‐mobilizing hormones elicit phosphatidylethanol accumulation via phospholipase D activation},
  author={Stephen B. Bocckino and P B Wilson and John H. Exton},
  journal={FEBS Letters},

Hormonal Regulation of Phospholipid Metabolism via G-Proteins: Phosphoinositide Phospholipase C and Phosphatidylcholine Phospholipase D

Many hormones, neurotransmitters, and growth factors produce their effects by inducing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdInsP2) in the plasma membranes of their target cells

Phosphatidylethanol formation in human platelets: evidence for thrombin-induced activation of phospholipase D.

  • R. Rubin
  • Biology, Chemistry
    Biochemical and biophysical research communications
  • 1988

Phorbol Esters Stimulate Phospholipase D Activity in C-6 Glioma Cells

It is demonstrated that TPA stimulates phospholipase D activity in cultured C-6 glioma cells and this increase was inhibited by ethanol.

Phorbol ester and vasopressin activate phospholipase D in leydig cells

Phospholipase D-derived Products in the Regulation of 12-O-Tetradecanoylphorbol-13-acetate-stimulated Prostaglandin Synthesis in Madin-Darby Canine Kidney Cells*

The demonstration that inhibition of TPA-induced PA formation inhibits Raf-1 translocation in MDCK cells suggests that PLD-derived PA or DG act as second messengers in the induction of PGHS-2 by PKC-dependent pathways.



Formation of phosphatidylethanol in rat brain by phospholipase D.

Relationship between stimulated phosphatidic acid production and inositol lipid hydrolysis in intestinal longitudinal smooth muscle from guinea pig.

The results suggest that an increase in formation of IPs is not necessarily accompanied by a increase in PA formation, and imply the existence of receptor-modulated pathways regulating PA concentrations other than by phospholipase-C-catalysed inositolospholipid hydrolysis.

The formation of phosphatidylglycerol and other phospholipids by the transferase activity of phospholipase D.

  • R. Dawson
  • Chemistry, Biology
    The Biochemical journal
  • 1967
Water-soluble alcohols can markedly stimulate the liberation of choline from ultrasonically treated lecithin by phospholipase D, usually due to an increase in hydrolase activity although often the associated transferase activity contributes.

Phosphatidylethanol Formation via Transphosphatidylation by Rat Brain Synaptosomal Phospholipase D

Peth formation catalyzed by the transphosphatidylation activity of phospholipase D was demonstrated to occur in a rat brain synaptosomal enriched preparation and phosphatidylethanol was the most effective phosphatIDyl donor of the phospho‐lipids tested.