Ca2+Channel Antagonists and Agonists

  title={Ca2+Channel Antagonists and Agonists},
  author={Satomi Adachi-Akahane and Takashi Nagao},
Ca2+channel antagonists were originally developed as coronary vasodilators. Ca2+antagonism, as a new principle of pharmacological action of coronary drugs, was reported by Albert Fleckenstein in 1964 (FLECKENSTEIN 1964). Shortly after that, verapamil, gallopamil (D600), nifedipine, and diltiazem were shown to suppress cardiac E-C coupling in that they abolished contractile force without a major change in the action potential. These drugs were termed Ca2+antagonists, because the inhibitory… CONTINUE READING