Ca2+ transient decline and myocardial relaxation are slowed during low flow ischemia in rat hearts.

@article{Camacho1994Ca2TD,
  title={Ca2+ transient decline and myocardial relaxation are slowed during low flow ischemia in rat hearts.},
  author={S. Albert Camacho and Rolf Brandes and Vincent M Figueredo and Michael W Weiner},
  journal={The Journal of clinical investigation},
  year={1994},
  volume={93 3},
  pages={
          951-7
        }
}
The mechanisms that impair myocardial relaxation during ischemia are believed to involve abnormalities of calcium handling. However, there is little direct evidence to support this hypothesis. Therefore, we sought to determine whether the time constant of cytosolic calcium ([Ca2+]c) decline (tau Ca) was increased during low flow ischemia, and if there was a relationship between the time constant of left ventricular pressure decline (tau P) and tau Ca. Isolated perfused hearts were studied using… CONTINUE READING

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