Ca2+-sparks constitute elementary building blocks for global Ca2+-signals in myocytes of retinal arterioles

@inproceedings{Tumelty2007Ca2sparksCE,
  title={Ca2+-sparks constitute elementary building blocks for global Ca2+-signals in myocytes of retinal arterioles},
  author={James Tumelty and Norman Scholfield and Michael T. Stewart and Tim M. Curtis and Graham McGeown},
  booktitle={Cell calcium},
  year={2007}
}
Spontaneous Ca2+-events were imaged in myocytes within intact retinal arterioles (diameter <40 microm) freshly isolated from rat eyes. Ca2+-sparks were often observed to spread across the width of these small cells, and could summate to produce prolonged Ca2+-oscillations and contraction. Application of cyclopiazonic acid (20 microM) transiently increased spark frequency and oscillation amplitude, but inhibited both sparks and oscillations within 60s. Both ryanodine (100 microM) and tetracaine… CONTINUE READING

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