Ca2+ signalling in urethral interstitial cells of Cajal.

  title={Ca2+ signalling in urethral interstitial cells of Cajal.},
  author={Gerard P Sergeant and Mark A. Hollywood and Noel G. McHale and Keith D. Thornbury},
  journal={The Journal of physiology},
  volume={576 Pt 3},
Interstitial cells of Cajal (ICC) in the urethra have been proposed as specialized pacemakers that are involved in the generation of urethral tone and therefore the maintenance of urinary continence. Recent studies on freshly dispersed ICC from the urethra of rabbits have demonstrated that pacemaker activity in urethra ICC is characterized by spontaneous transient depolarizations (STDs) under current clamp and spontaneous transient inward currents (STICs) under voltage clamp. When these events… CONTINUE READING


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