Ca2+-signaling cycle of a membrane-docking C2 domain.

  title={Ca2+-signaling cycle of a membrane-docking C2 domain.},
  author={Eric A. Nalefski and M M Slazas and Joseph J. Falke},
  volume={36 40},
The C2 domain is a Ca2+-dependent, membrane-targeting motif originally discovered in protein kinase C and recently identified in numerous eukaryotic signal-transducing proteins, including cytosolic phospholipase A2 (cPLA2) of the vertebrate inflammation pathway. Intracellular Ca2+ signals recruit the C2 domain of cPLA2 to cellular membranes where the enzymatic domain hydrolyzes specific lipids to release arachidonic acid, thereby initiating the inflammatory response. Equilibrium binding and… CONTINUE READING

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