Ca2+-sensitive inactivation of L-type Ca2+ channels depends on multiple cytoplasmic amino acid sequences of the alpha1C subunit.

@article{Zhlke1998Ca2sensitiveIO,
  title={Ca2+-sensitive inactivation of L-type Ca2+ channels depends on multiple cytoplasmic amino acid sequences of the alpha1C subunit.},
  author={Roger D. Z{\"u}hlke and Harald Reuter},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 6},
  pages={3287-94}
}
Ca2+-dependent inactivation of Ca2+ currents is a physiological phenomenon widely associated with L-type Ca2+ channels. Although the pore-forming alpha1C subunit of the channel is the target for Ca2+ binding, the amino acid sequences involved in the binding and/or in the coordination of Ca2+-dependent inactivation are still unclear. Based on previous experiments, we have prepared truncation mutants of a human alpha1C subunit by systematically deleting an EF-hand motif and sequences in a segment… CONTINUE READING
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