Ca2+ regulation of tight-junction permeability and structure in Necturus gallbladder.

@article{Palant1983Ca2RO,
  title={Ca2+ regulation of tight-junction permeability and structure in Necturus gallbladder.},
  author={Carlos E. Palant and Michael E. Duffey and B K Mookerjee and Shu Leong Ho and Carl J. Bentzel},
  journal={The American journal of physiology},
  year={1983},
  volume={245 3},
  pages={C203-12}
}
To explore the role of Ca2+ in tight-junction permeability, the Necturus gallbladder was exposed to varying Ca2+ concentrations and to the Ca2+ ionophore A23187 added to the mucosal side (1.9 X 10(-6) to 6.8 X 10(-5) M). Electrophysiological parameters measured in an Ussing-type chamber were correlated with tight-junction morphology revealed by freeze-fracture electron microscopy. In Ca2+-free bathing media, transepithelial resistance decreases and tight-junctional ultrastructure is fragmented… CONTINUE READING

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