Ca2+-regulated-cAMP/PKA signaling in cardiac pacemaker cells links ATP supply to demand.

@article{Yaniv2011Ca2regulatedcAMPPKASI,
  title={Ca2+-regulated-cAMP/PKA signaling in cardiac pacemaker cells links ATP supply to demand.},
  author={Yael Yaniv and Magdalena Juhaszova and Alexey Lyashkov and Harold Albert Spurgeon and Steven J. Sollott and Edward G. Lakatta},
  journal={Journal of molecular and cellular cardiology},
  year={2011},
  volume={51 5},
  pages={
          740-8
        }
}
RATIONALE In sinoatrial node cells (SANC), Ca(2+) activates adenylate cyclase (AC) to generate a high basal level of cAMP-mediated/protein kinase A (PKA)-dependent phosphorylation of Ca(2+) cycling proteins. These result in spontaneous sarcoplasmic-reticulum (SR) generated rhythmic Ca(2+) oscillations during diastolic depolarization, that not only trigger the surface membrane to generate rhythmic action potentials (APs), but, in a feed-forward manner, also activate AC/PKA signaling. ATP is… CONTINUE READING
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