Ca2+ oscillations stimulate an ATP increase during fertilization of mouse eggs.

@article{Campbell2006Ca2OS,
  title={Ca2+ oscillations stimulate an ATP increase during fertilization of mouse eggs.},
  author={Karen M. Campbell and Karl Swann},
  journal={Developmental biology},
  year={2006},
  volume={298 1},
  pages={225-33}
}
Mammalian eggs and embryos rely upon mitochondrial ATP production to survive and proceed through preimplantation development. Ca(2+) oscillations at fertilization have been shown to cause a reduction of mitochondrial NAD+ and flavoproteins, suggesting they might also cause changes in cytosolic ATP levels. Here, we have monitored intracellular Ca(2+) and ATP levels in fertilizing mouse eggs by imaging the fluorescence of a Ca(2+) dye and luminescence of firefly luciferase. At fertilization an… CONTINUE READING
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