Ca2+ microdomains near plasma membrane Ca2+ channels: impact on cell function

@article{Parekh2008Ca2MN,
  title={Ca2+ microdomains near plasma membrane Ca2+ channels: impact on cell function},
  author={A. Parekh},
  journal={The Journal of Physiology},
  year={2008},
  volume={586}
}
  • A. Parekh
  • Published 2008
  • Biology, Medicine
  • The Journal of Physiology
In eukaryotic cells, a rise in cytoplasmic Ca2+ can activate a plethora of responses that operate on time scales ranging from milliseconds to days. Inherent to the use of a promiscuous signal like Ca2+ is the problem of specificity: how can Ca2+ activate some responses but not others? We now know that the spatial profile of the Ca2+ signal is important Ca2+ does not simply rise uniformly throughout the cytoplasm upon stimulation but can reach very high levels locally, creating spatial gradients… Expand
196 Citations
Signaling through Ca2+ Microdomains from Store-Operated CRAC Channels.
  • 4
STIM1 and Orai1 regulate Ca2+ microdomains for activation of transcription.
  • 4
The dynamic complexity of the TRPC1 channelosome
  • 51
Capacitative calcium entry: from concept to molecules
  • J. Putney
  • Biology, Medicine
  • Immunological reviews
  • 2009
  • 208
Local Ca2+ influx through CRAC channels activates temporally and spatially distinct cellular responses
  • A. Parekh
  • Biology, Medicine
  • Acta physiologica
  • 2009
  • 14
STIM proteins, Orai1, and gene expression
  • 11
CRAC channels and Ca2+ signaling in mast cells
  • 72
Direct demonstration of discrete Ca2+ microdomains associated with different isoforms of adenylyl cyclase
  • 55
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 103 REFERENCES
Modulation of plasma membrane calcium‐ATPase activity by local calcium microdomains near CRAC channels in human T cells
  • 92
  • Highly Influential
Calcium regulates exocytosis at the level of single vesicles
  • 147
Microdomains of intracellular Ca2+: molecular determinants and functional consequences.
  • 1,031
Ca2+ modulation of volume‐regulated anion channels: evidence for colocalization with store‐operated channels
  • 36
Calmodulin supports both inactivation and facilitation of L-type calcium channels
  • 818
Depletion of intracellular calcium stores activates a calcium current in mast cells
  • 1,662
  • PDF
Store-operated calcium channels.
  • 2,228
  • PDF
Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores.
  • A. Zweifach, R. S. Lewis
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1993
  • 705
  • Highly Influential
  • PDF
Capacitative calcium entry supports calcium oscillations in human embryonic kidney cells
  • 117
...
1
2
3
4
5
...