Ca2+-mediated Mitochondrial Reactive Oxygen Species Metabolism Augments Wnt/β-Catenin Pathway Activation to Facilitate Cell Differentiation*

@inproceedings{Rharass2014Ca2mediatedMR,
  title={Ca2+-mediated Mitochondrial Reactive Oxygen Species Metabolism Augments Wnt/β-Catenin Pathway Activation to Facilitate Cell Differentiation*},
  author={Tareck Rharass and Heiko Lemcke and Margareta Lantow and Sergei Kuznetsov and Dieter G. Weiss and Daniela Pan{\'a}kov{\'a}},
  booktitle={The Journal of biological chemistry},
  year={2014}
}
Emerging evidence suggests that reactive oxygen species (ROS) can stimulate the Wnt/β-catenin pathway in a number of cellular processes. However, potential sources of endogenous ROS have not been thoroughly explored. Here, we show that growth factor depletion in human neural progenitor cells induces ROS production in mitochondria. Elevated ROS levels augment activation of Wnt/β-catenin signaling that regulates neural differentiation. We find that growth factor depletion stimulates the release… CONTINUE READING
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