Ca2+ influx through alpha1S DHPR may play a role in regulating Ca2+ release from RyR1 in skeletal muscle.

@article{Shtifman2004Ca2IT,
  title={Ca2+ influx through alpha1S DHPR may play a role in regulating Ca2+ release from RyR1 in skeletal muscle.},
  author={Alexander Shtifman and C. P. Paolini and Jos{\'e} Rafael L{\'o}pez and Paul D. Allen and Feliciano Protasi},
  journal={American journal of physiology. Cell physiology},
  year={2004},
  volume={286 1},
  pages={C73-8}
}
Differentiated primary myotubes isolated from wild-type mice exhibit ryanodine-sensitive, spontaneous global Ca2+ oscillations as well as spontaneous depolarizations in the plasma membrane. Immunolabeling of these myotubes showed expression of both alpha1S dihydropyridine receptors (DHPRs) and ryanodine-sensitive Ca2+-release channel 1 (RyR1), the two key… CONTINUE READING