Ca2+ influx pathways mediated by swelling or stores depletion in mouse thymocytes

@article{Ross1995Ca2IP,
  title={Ca2+ influx pathways mediated by swelling or stores depletion in mouse thymocytes},
  author={Paul E. Ross and Michael D Cahalan},
  journal={The Journal of General Physiology},
  year={1995},
  volume={106},
  pages={415 - 444}
}
We used fura-2 video imaging to characterize two Ca2+ influx pathways in mouse thymocytes. Most thymocytes (77%) superfused with hypoosmotic media (60% of isoosmotic) exhibited a sharp, transient rise in the concentration of intracellular free Ca2+ ([Ca2+]i). After a delay of approximately 70 s, these swelling-activated [Ca2+]i (SWAC) transients reached approximately 650 nM from resting levels of approximately 100 nM and declined from a time constant of 20 s. Peak [Ca2+]i during transients… CONTINUE READING
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Swelling-and depletion-activated Ca 2+ influx pathways in mouse thymocytes

  • P E Ross, M D Cahalan
  • Biophysical Journal
  • 1995

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