Ca2+ influx mediates apoptosis induced by 4-aminopyridine, a K+ channel blocker, in HepG2 human hepatoblastoma cells.

@article{Kim2000Ca2IM,
  title={Ca2+ influx mediates apoptosis induced by 4-aminopyridine, a K+ channel blocker, in HepG2 human hepatoblastoma cells.},
  author={J A Kim and Young Shin Kang and Min Whan Jung and Gyung Hwa Kang and Sung Hee Lee and Yong Soo Lee},
  journal={Pharmacology},
  year={2000},
  volume={60 2},
  pages={74-81}
}
Apoptosis appears to be implicated in the pathogenesis and therapeutic applications of cancer. In this study we investigated the induction of apoptosis by 4-aminopyridine (4-AP), a K(+) channel blocker, and its mechanism in HepG2 human hepatoblastoma cells. 4-AP reduced cell viability and induced DNA fragmentation, a hallmark of apoptosis, in a dose-dependent manner. In addition, 4-AP induced a sustained increase in intracellular Ca(2+) concentration, which was completely inhibited by the… CONTINUE READING

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