Ca2+ influx is an essential component of the positive-feedback loop that maintains leading-edge structure and activity in macrophages.

@article{Evans2007Ca2II,
  title={Ca2+ influx is an essential component of the positive-feedback loop that maintains leading-edge structure and activity in macrophages.},
  author={John H. Evans and Joseph J. Falke},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 41},
  pages={16176-81}
}
In migrating eukaryotic cells, phosphatidylinositol 3-kinase (PI3K), filamentous actin (F-actin), and monomeric Rho GTPases are key components of a complex positive-feedback system that maintains and amplifies a phosphatidylinositol-3,4,5-trisphosphate signal at the leading edge of the cell. This lipid signal is required for cell polarization and movement. In leukocytes and Dictyostelium, activation or inhibition of any one of these components leads to the activation or inhibition, respectively… CONTINUE READING

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