Ca2+ induces charybdotoxin-sensitive membrane potential changes in rat lymphocytes.

@article{Grinstein1989Ca2IC,
  title={Ca2+ induces charybdotoxin-sensitive membrane potential changes in rat lymphocytes.},
  author={Sergio Grinstein and Joshua D. Smith},
  journal={The American journal of physiology},
  year={1989},
  volume={257 2 Pt 1},
  pages={C197-206}
}
There is disagreement regarding the existence of Ca2+-activated K+ channels in lymphocytes. Depolarization, hyperpolarization, or little change in membrane potential (Em) has been reported following elevation of free cytosolic Ca2+ concentration ([Ca2+]i). Patch-clamping studies have demonstrated inhibition of voltage-gated K+ channels, but Ca2+-activated K+ channels have not been detected. We used charybdotoxin (CTX), a potent inhibitor of Ca2+-activated K+ channels, to assess their presence… CONTINUE READING

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