Ca2+-induced Ca2+ release activates K+ currents by a cyclic GMP-dependent mechanism in single gastric smooth muscle cells

@article{Duridanova1996Ca2inducedCR,
  title={Ca2+-induced Ca2+ release activates K+ currents by a cyclic GMP-dependent mechanism in single gastric smooth muscle cells},
  author={Dessislava B. Duridanova and Hristo S Gagov and Kiril K. Boev},
  journal={European Journal of Pharmacology},
  year={1996},
  volume={298},
  pages={159-163}
}
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References

SHOWING 1-10 OF 18 REFERENCES
Cyclic GMP-induced activation of potassium currents by sarcoplasmic reticulum Ca2+ pump-dependent mechanism.
TLDR
The authors' data suggest that, in gastric fundus smooth muscles, NO-liberating substances and cGMP analogues contribute to the activation of a Ca2+ -release mechanism from the cell bulk, i.e. the myoplasm surrounding the contractile filaments, towards the plasma membrane, crossing the SR Ca2-stores.
Regulation of intracellular Ca2+ levels in cultured vascular smooth muscle cells. Reduction of Ca2+ by atriopeptin and 8-bromo-cyclic GMP is mediated by cyclic GMP-dependent protein kinase.
TLDR
It is suggested that repetitively passaged cultured rat aortic smooth muscle cells lose their responsiveness to cGMP concurrently with the loss of cG MP-dependent protein kinase, and restoration of kinase to the cells results in the restoration of responsiveness tocGMP.
Sodium nitroprusside alters Ca2+ flux components and Ca2(+)‐dependent fluxes of K+ and Cl‐ in rat aorta.
TLDR
NP reduces cytosolic Ca2+, by the combined inhibitory effects on Ca2+ influx and intracellular Ca2- release, and by the stimulation of a Ca2(+)‐ATPase; and the differential sensitivity of the NA and high‐potassium responses to NP may reflect underlying differences inCa2+ handling induced by receptor occupancy and depolarization.
Cytosolic heparin inhibits muscarinic and alpha-adrenergic Ca2+ release in smooth muscle. Physiological role of inositol 1,4,5-trisphosphate in pharmacomechanical coupling.
TLDR
It is shown that in smooth muscle permeabilized with beta-escin, one of the saponin esters, alpha 1-adrenergic and muscarinic agonists, as well as caffeine and InsP3, cause contractions mediated by Ca2+ release, which supports the conclusion that InsP 3 is the major physiological messenger of the Ca 2+ release component of pharmacomechanical coupling.
Calcium-induced calcium release mechanism in guinea pig taenia caeci
  • M. Iino
  • Biology
    The Journal of general physiology
  • 1989
TLDR
Rates of the CICR under a physiological ionic milieu were estimated from the results, and a [Ca2+] greater than 1 microM was expected to be necessary for the activation of the Ca release.
Cellular mechanisms regulating [Ca2+]i smooth muscle.
TLDR
This chapter discusses the Ca2+ transport mechanisms that determine the intracellular Ca 2+ concentration ([Ca2+U]], and thus regulate smooth muscle contraction.
Suppression of steady membrane currents by acetylcholine in single smooth muscle cells of the guinea‐pig gastric fundus.
TLDR
A major mechanism underlying muscarinic activation is a decrease of a K+ conductance in fundus muscle of the guinea‐pig stomach, and results indicate a suppression of a small Na+ Conductance which is made up by a population of channels that are also blocked by TEA.
Spontaneous sarcoplasmic reticulum calcium release and extrusion from bovine, not porcine, coronary artery smooth muscle.
1. We tested the hypothesis that the Ca(2+)‐loaded sarcoplasmic reticulum (SR) of coronary artery smooth muscle spontaneously releases Ca2+ preferentially toward the sarcolemma to be extruded from
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