Ca2+-independent phospholipase A2 is a novel determinant of store-operated Ca2+ entry.

@article{Smani2003Ca2independentPA,
  title={Ca2+-independent phospholipase A2 is a novel determinant of store-operated Ca2+ entry.},
  author={Tarik Smani and Sergey I. Zakharov and Endri Leno and P{\'e}ter Csutora and Elena S. Trepakova and Victoria M. Bolotina},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 14},
  pages={11909-15}
}
Store-operated cation (SOC) channels and capacitative Ca(2+) entry (CCE) play very important role in cellular function, but the mechanism of their activation remains one of the most intriguing and long lasting mysteries in the field of Ca(2+) signaling. Here, we present the first evidence that Ca(2+)-independent phospholipase A(2) (iPLA(2)) is a crucial molecular determinant in activation of SOC channels and store-operated Ca(2+) entry pathway. Using molecular, imaging, and electrophysiological… CONTINUE READING

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