Ca2+-independent excitotoxic neurodegeneration in isolated retina, an intact neural net: a role for Cl- and inhibitory transmitters.

@article{Chen1998Ca2independentEN,
  title={Ca2+-independent excitotoxic neurodegeneration in isolated retina, an intact neural net: a role for Cl- and inhibitory transmitters.},
  author={Q X Chen and John W. Olney and Peter D. Lukasiewicz and T Almli and Carmelo Romano},
  journal={Molecular pharmacology},
  year={1998},
  volume={53 3},
  pages={
          564-72
        }
}
Rapidly triggered excitotoxic cell death is widely thought to be due to excessive influx of extracellular Ca2+, primarily through the N-methyl-D-aspartate subtype of glutamate receptor. By devising conditions that permit the maintenance of isolated retina in the absence of Ca2+, it has become technically feasible to test the dependence of excitotoxic neurodegeneration in this intact neural system on extracellular Ca2+. Using biochemical, Ca2+ imaging, and electrophysiological techniques, we… CONTINUE READING

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