Ca2+ in quality control: an unresolved riddle critical to autophagy and mitophagy.

@article{East2013Ca2IQ,
  title={Ca2+ in quality control: an unresolved riddle critical to autophagy and mitophagy.},
  author={Daniel Alistair East and Michelangelo Campanella},
  journal={Autophagy},
  year={2013},
  volume={9 11},
  pages={
          1710-9
        }
}
Calcium (Ca (2+)) has long been known as a ubiquitous intracellular second messenger, exploited by cells to control processes as diverse as development, proliferation, learning, muscle contraction and secretion. The spatial and temporal patterns of these Ca (2+)-associated signals, as well as their amplitude, is precisely controlled to create gradients of the ion, varying considerably depending on cell type and function. Tuning of intracellular Ca (2+) is achieved in part by the buffering role… CONTINUE READING
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