Ca2+ flux in human placental trophoblasts.

  title={Ca2+ flux in human placental trophoblasts.},
  author={Peter I. Karl and Jesse Chusid and Clement Tagoe and Stanley E. Fisher},
  journal={The American journal of physiology},
  volume={272 6 Pt 1},
Intracellular Ca2+ is an important second messenger. In the placenta, regulation of intracellular Ca2+ concentration ([Ca2+]i) by extracellular factors has received relatively little attention. Cultured human placental trophoblasts were treated with a series of potential Ca(2+)-mobilizing ligands. After 3 days in culture, there was an increase in [Ca2+]i in response to angiotensin, endothelin, transforming growth factor-alpha, and ATP in approximately 8, 54, 17, and 100% of the cells… CONTINUE READING