Ca2+ excitability of the ER membrane: an explanation for IP3-induced Ca2+ oscillations.

@article{Li1995Ca2EO,
  title={Ca2+ excitability of the ER membrane: an explanation for IP3-induced Ca2+ oscillations.},
  author={Yanjun Li and Joel Keizer and Stanko S. Stojilkovic and John Rinzel},
  journal={The American journal of physiology},
  year={1995},
  volume={269 5 Pt 1},
  pages={
          C1079-92
        }
}
Recent research dealing with experiments and theoretical models of Ca2+ excitability of the endoplasmic reticulum (ER) membrane induced by inositol 1,4,5-trisphosphate (IP3) is reviewed. Ca2+ excitability refers to the ability of a small increment of cytoplasmic Ca2+ concentration ([Ca2+]i) to trigger a large [Ca2+]i pulse or oscillations. Such nonlinear regenerative behavior is conferred by the existence of IP3 channels and Ca(2+)-ATPase transporters on the ER membrane, which extends… CONTINUE READING
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