Ca2+-desensitizing effect of a deletion mutation ΔK210 in cardiac troponin T that causes familial dilated cardiomyopathy

@article{Morimoto2002Ca2desensitizingEO,
  title={Ca2+-desensitizing effect of a deletion mutation $\Delta$K210 in cardiac troponin T that causes familial dilated cardiomyopathy},
  author={S. Morimoto and Q. Lu and K. Harada and F. Takahashi‐Yanaga and R. Minakami and M. Ohta and T. Sasaguri and I. Ohtsuki},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99},
  pages={913 - 918}
}
  • S. Morimoto, Q. Lu, +5 authors I. Ohtsuki
  • Published 2002
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
A deletion mutation ΔK210 in cardiac troponin T (cTnT) was recently found to cause familial dilated cardiomyopathy (DCM). To explore the effect of this mutation on cardiac muscle contraction under physiological conditions, we determined the Ca2+-activated force generation in permeabilized rabbit cardiac muscle fibers into which the mutant and wild-type cTnTs were incorporated by using our TnT exchange technique. The free Ca2+ concentrations required for the force generation were higher in the… Expand
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