Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in skeletal and cardiac muscle.

@article{Murphy2013Ca2dependentPO,
  title={Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in skeletal and cardiac muscle.},
  author={Robyn M Murphy and Travis L. Dutka and Denis Horvath and James R G Bell and Lea M Delbridge and G. D. Lamb},
  journal={The Journal of physiology},
  year={2013},
  volume={591 3},
  pages={719-29}
}
Excessive increases in intracellular [Ca(2+)] in skeletal muscle fibres cause failure of excitation-contraction coupling by disrupting communication between the dihydropyridine receptors in the transverse tubular system and the Ca(2+) release channels (RyRs) in the sarcoplasmic reticulum (SR), but the exact mechanism is unknown. Previous work suggested a possible role of Ca(2+)-dependent proteolysis in this uncoupling process but found no proteolysis of the dihydropyridine receptors, RyRs or… CONTINUE READING