Ca2+-dependent mechanisms of presynaptic control at central synapses.

  title={Ca2+-dependent mechanisms of presynaptic control at central synapses.},
  author={Dmitri A. Rusakov},
  journal={The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  volume={12 4},
Classically, a high-power association relates the neurotransmitter release probability to the concentration of presynaptic Ca2+. Activated by the action potential waveform, voltage-gated Ca2+ channels mediate Ca2+entry into presynaptic terminals. Inside the terminal, Ca2+ ions rapidly bind to endogenous intracellular buffers and could trigger Ca2+ release from internal Ca2+ stores. The resulting space-time profile of free Ca2+ determines the time course and probability of neurotransmitter… CONTINUE READING

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