Ca2+-dependent deimination-induced disassembly of intermediate filaments involves specific modification of the amino-terminal head domain.

@article{Inagaki1989Ca2dependentDD,
  title={Ca2+-dependent deimination-induced disassembly of intermediate filaments involves specific modification of the amino-terminal head domain.},
  author={Masaki Inagaki and Hidenari Takahara and Yoshimi Nishi and Klyoshi Sugawara and Chikako Sato},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 30},
  pages={18119-27}
}
Peptidylarginine deiminase (proteinarginine iminohydrolase, EC 3.5.3.15) converted some arginine residues to citrulline residues in soluble vimentin, in a micromolar Ca2+-dependent manner and resulted in the loss of polymerization competence of the intermediate filament protein. When about 8 mol of residues/mol of vimentin were deiminated, there was a complete loss of filament forming ability. This enzyme also deiminated vimentin filaments which had been polymerized, and deimination of vimentin… CONTINUE READING

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