Ca2+-dependent conversion of phosphatidylinositol to phosphatidate in neutrophils stimulated with fMet-Leu-Phe or ionophore A23187.

@article{Cockcroft1984Ca2dependentCO,
  title={Ca2+-dependent conversion of phosphatidylinositol to phosphatidate in neutrophils stimulated with fMet-Leu-Phe or ionophore A23187.},
  author={Shamshad Cockcroft},
  journal={Biochimica et biophysica acta},
  year={1984},
  volume={795 1},
  pages={37-46}
}
Human and rabbit neutrophils stimulated with formylmethionyl-leucyl-phenylalanine (fMet-Leu-Phe) and A23187 show a loss of phosphatidylinositol and an increase in phosphatidate. In cells prelabelled with 32Pi it would be expected that the newly synthesised phosphatidate would have the same specific activity as cellular ATP, provided that the loss of phosphatidylinositol is by phospholipase C attack and the resultant diacyglycerol is phosphorylated by ATP. Instead, it is demonstrated that the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

20 years of Ins(1,4,5)P3, and 40 years before

Nature Reviews Molecular Cell Biology • 2003

Similar Papers

Loading similar papers…