Ca2+-dependent calcineurin/NFAT signaling in β-adrenergic-induced cardiac hypertrophy.

Abstract

Ca2+ is an important mediator in the β-adrenergic-induced cardiac hypertrophy. The β-adrenergic stimulation alters the Ca2+ transient characteristics including its oscillation frequency, diastolic and systolic levels which lead to the CaN activation and subsequent NFAT-dependent hypertrophic genes transcription. Moreover, β-adrenergic-induced alterations in… (More)
DOI: 10.4149/gpb_2017022

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