Ca2+-dependent K+ Channels in Bovine Adrenal Chromaffin Cells are Modulated by Lipoxygenase Metabolites of Arachidonic Acid

@article{Twitchell1997Ca2dependentKC,
  title={Ca2+-dependent K+ Channels in Bovine Adrenal Chromaffin Cells are Modulated by Lipoxygenase Metabolites of Arachidonic Acid},
  author={Wayne A. Twitchell and T Julio Pe{\~n}a and Stanley G. Rane},
  journal={The Journal of Membrane Biology},
  year={1997},
  volume={158},
  pages={69-75}
}
Fatty acids play an important role in a variety of physiological processes including ion channel modulation and catecholamine release. Using patch-clamp techniques we show that arachidonic acid (AA) is converted to lipoxygenase metabolites (LOMs) to potentiate activity of the Ca2+ and voltage-dependent, large-conductance K+ channel (BK) in bovine adrenal medullary chromaffin cells (BAMCCs). AA and LOM potentiation of BK current and recovery from potentiation were unaffected by the… CONTINUE READING
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