Ca2+-dependent 4-aminopyridine- and α-latrotoxin-evoked [14C] GABA release has different sensitivity to protein kinase inhibitors

Synaptosomes from the rat brain were used to study the influence of protein kinase inhibitors on the plasma membrane calcium permeability and calcium-dependent α-latrotoxin (LTX)-induced [14C] GABA release. It was shown that stimulated by depolarization with 4-aminopyridine (4-AP) calcium permeability was inhibited by sphingosine. Calcium permeability… CONTINUE READING