Ca2+ current enhancement by alpha 2/delta and beta subunits in Xenopus oocytes: contribution of changes in channel gating and alpha 1 protein level.

@article{Shistik1995Ca2CE,
  title={Ca2+ current enhancement by alpha 2/delta and beta subunits in Xenopus oocytes: contribution of changes in channel gating and alpha 1 protein level.},
  author={Elena Shistik and Tatiana Ivanina and Tarun Puri and M. Marlene Hosey and Nathan Dascal},
  journal={The Journal of physiology},
  year={1995},
  volume={489 ( Pt 1)},
  pages={55-62}
}
1. A combined biochemical and electrophysiological approach was used to determine the mechanism by which the auxiliary subunits of Ca2+ channel enhance the macroscopic Ca2+ currents. Xenopus oocytes were injected with RNA of the main pore-forming subunit (cardiac: alpha 1C), and various combinations of RNAs of the auxiliary subunits (alpha 2/delta and beta 2A). 2. The single channel open probability (Po; measured at 0 mV) was increased approximately 3-, approximately 8- and approximately 35… CONTINUE READING

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