Ca2+ controls functional expression of the cardiac K+ transient outward current via the calcineurin pathway.

@article{Perrier2004Ca2CF,
  title={Ca2+ controls functional expression of the cardiac K+ transient outward current via the calcineurin pathway.},
  author={Emeline Perrier and Romain Perrier and Sylvain Richard and Jean-Pierre Benitah},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 39},
  pages={40634-9}
}
The transient outward K+ current (Ito) modulates transmembrane Ca2+ influx into cardiomyocytes, which, in turn, might act on Ito. Here, we investigated whether Ca2+ modifies functional expression of Ito. Whole-cell Ito were recorded using the patch clamp technique in single right ventricular myocytes isolated from adult rats and incubated for 24 h at 37 degrees C in a serum-free medium containing various Ca2+ concentrations ([Ca2+]o). Increasing the [Ca2+]o from 0.5 to 1.0 and 2.5 mM produced a… CONTINUE READING
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