Ca2+ control of actin filament length. Effects of macrophage gelsolin on actin polymerization.

@article{Yin1981Ca2CO,
  title={Ca2+ control of actin filament length. Effects of macrophage gelsolin on actin polymerization.},
  author={Helen L. Yin and John H. Hartwig and Kosçak Maruyama and Thomas Peter Stossel},
  journal={The Journal of biological chemistry},
  year={1981},
  volume={256 18},
  pages={9693-7}
}
Gelsolin complexes with calcium (gelsolin-Ca2+) binds to the ends of actin filaments to which monomers add preferentially during elongation. It forms a stable complex with actin in a low ionic strength solution which does not normally favor the polymerization of actin. Gelsolin-Ca2+ increases the rate of nucleation of actin which precedes polymerization, but decreases the rate of elongation of the filaments. The final average length of filaments formed in the presence of gelsolin-Ca2+ is… CONTINUE READING

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