Ca2+ channels, ryanodine receptors and Ca(2+)-activated K+ channels: a functional unit for regulating arterial tone.

@article{Jaggar1998Ca2CR,
  title={Ca2+ channels, ryanodine receptors and Ca(2+)-activated K+ channels: a functional unit for regulating arterial tone.},
  author={Jonathan H Jaggar and George C. Wellman and Thomas J. Heppner and Valerie A Porter and Guillermo Juli{\'a}n Gonz{\'a}lez P{\'e}rez and Maik Gollasch and Thomas Kleppisch and Michael Rubart and Andr{\'a} S Stevenson and W. Jonathan Lederer and Harm J. Knot and Adrian D. Bonev and Mark T. Nelson},
  journal={Acta physiologica Scandinavica},
  year={1998},
  volume={164 4},
  pages={
          577-87
        }
}
Local calcium transients ('Ca2+ sparks') are thought to be elementary Ca2+ signals in heart, skeletal and smooth muscle cells. Ca2+ sparks result from the opening of a single, or the coordinated opening of many, tightly clustered ryanodine receptor (RyR) channels in the sarcoplasmic reticulum (SR). In arterial smooth muscle, Ca2+ sparks appear to be involved in opposing the tonic contraction of the blood vessel. Intravascular pressure causes a graded membrane potential depolarization to… CONTINUE READING

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