Ca2+ channel and adenylyl cyclase modulation by cloned mu-opioid receptors in GH3 cells.

@article{Piros1995Ca2CA,
  title={Ca2+ channel and adenylyl cyclase modulation by cloned mu-opioid receptors in GH3 cells.},
  author={Elemer T. Piros and Paul L. Prather and Horace H. Loh and Ping-Yee Law and C. John Evans and Tim G Hales},
  journal={Molecular pharmacology},
  year={1995},
  volume={47 5},
  pages={1041-9}
}
Members of the three classes of opioid receptors (mu, delta, and kappa) have been cloned and characterized in unexcitable cell lines using biochemical techniques. However, an important function of these cloned receptors, their coupling to voltage-activated Ca2+ channels, remains untested. We stably transfected cloned rat mu-opioid receptor cDNAs into clonal pituitary GH3 cells. GH3 cells expressing mu-opioid receptors (GH3MOR cells) bound the receptor-specific ligands [D-Ala2,Me-Phe4,Gly-ol5… CONTINUE READING

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