Ca2+-binding protein-1 facilitates and forms a postsynaptic complex with Cav1.2 (L-type) Ca2+ channels.

@article{Zhou2004Ca2bindingPF,
  title={Ca2+-binding protein-1 facilitates and forms a postsynaptic complex with Cav1.2 (L-type) Ca2+ channels.},
  author={Hong Zhou and Seong-Ah Kim and Elizabeth A. Kirk and Alyssa L Tippens and Hong Shuo Sun and Françoise Haeseleer and Amy Lee},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 19},
  pages={4698-708}
}
Ca2+-binding protein-1 (CaBP1) is a Ca2+-binding protein that is closely related to calmodulin (CaM) and localized in somatodendritic regions of principal neurons throughout the brain, but how CaBP1 participates in postsynaptic Ca2+ signaling is not known. Here, we describe a novel role for CaBP1 in the regulation of Ca2+ influx through Ca(v)1.2 (L-type) Ca2+ channels. CaBP1 interacts directly with the alpha1 subunit of Ca(v)1.2 at sites that also bind CaM. CaBP1 binding to one of these sites… CONTINUE READING

7 Figures & Tables

Connections & Topics

Mentioned Connections BETA
Moreover , in double - label immunofluorescence experiments , CaBP1 and Ca(v)1.2 colocalize in numerous cell bodies and dendrites of neurons , particularly in pyramidal cells in the CA3 region of the hippocampus and in the dorsal cortex .
Moreover , in double - label immunofluorescence experiments , CaBP1 and Ca(v)1.2 colocalize in numerous cell bodies and dendrites of neurons , particularly in pyramidal cells in the CA3 region of the hippocampus and in the dorsal cortex .
Moreover , in double - label immunofluorescence experiments , CaBP1 and Ca(v)1.2 colocalize in numerous cell bodies and dendrites of neurons , particularly in pyramidal cells in the CA3 region of the hippocampus and in the dorsal cortex .
Moreover , in double - label immunofluorescence experiments , CaBP1 and Ca(v)1.2 colocalize in numerous cell bodies and dendrites of neurons , particularly in pyramidal cells in the CA3 region of the hippocampus and in the dorsal cortex .
All Topics