Ca2+ antagonists effect an antidepressant-like adaptation of the NMDA receptor complex.

@article{Nowak1993Ca2AE,
  title={Ca2+ antagonists effect an antidepressant-like adaptation of the NMDA receptor complex.},
  author={G. Nowak and Ian A. Paul and Piotr Popik and Andrew Young and Phil Skolnick},
  journal={European journal of pharmacology},
  year={1993},
  volume={247 1},
  pages={101-2}
}
Chronic, but not acute treatment of mice with nimodipine and diltiazem produce significant increases in the IC50 of glycine to inhibit [3H]5,7-dichlorokynurenic acid binding in cerebral cortex. Such adaptive changes in the ligand binding properties of the NMDA receptor complex are also manifested following chronic treatment with antidepressants from every… CONTINUE READING