Ca2+ and protein kinase C activation of mucin granule exocytosis in permeabilized SPOC1 cells.

@article{Scott1998Ca2AP,
  title={Ca2+ and protein kinase C activation of mucin granule exocytosis in permeabilized SPOC1 cells.},
  author={Corey E. Scott and Lubna H. Abdullah and Christiana W Davis},
  journal={American journal of physiology. Cell physiology},
  year={1998},
  volume={275 1},
  pages={C285-C292}
}
Mucin secretion by airway goblet cells is under the control of apical P2Y2, phospholipase C-coupled purinergic receptors. In SPOC1 cells, the mobilization of intracellular Ca2+ by ionomycin or the activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) stimulates mucin secretion in a fully additive fashion [L. H. Abdullah, J. D. Conway, J. A. Cohn, and C. W. Davis. Am. J. Physiol. 273 ( Lung Cell. Mol. Physiol. 17): L201-L210, 1997]. This apparent independence between PKC… CONTINUE READING

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