Ca2+ and BMP-6 Signaling Regulate E2F during Epidermal Keratinocyte Differentiation*

  title={Ca2+ and BMP-6 Signaling Regulate E2F during Epidermal Keratinocyte Differentiation*},
  author={Sudhir J. A. D'souza and Agnieszka Katarzyna Pająk and Kim Balazsi and Lina Dagnino},
  journal={The Journal of Biological Chemistry},
  pages={23531 - 23538}
The epidermis consists of a squamous epithelium continuously replenished by committed stem cells, which can either self-renew or differentiate. We demonstrated previously that E2F genes are differentially expressed in developing epidermis (Dagnino, L., Fry, C. J., Bartley, S. M., Farnham, P., Gallie, B. L., and Phillips, R. A. (1997) Cell Growth Differ. 8, 553–563). Thus, we hypothesized that various E2F proteins likely play distinct growth regulatory roles in the undifferentiated stem cells… 

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